Endocrine Abstracts

Objective: Estrogen receptors α and β are members of the nuclear receptor family which regulate target gene expression in response to estrogens and to growth factor receptors-mediated pathways. CXCR4 is a chemokine receptor whose physiological ligand is the stromal-derived-factor-1 (SDF-1), a chemokine with proliferative and chemotactic functions. Recently, we reported that ERβ activity can be modulated by the tyrosine kinase ErbB2/ErbB3 receptors and also by th...